Maryam Karimifard; Seyed Jalal Eshagh Hoseini; Ashraf Mohamadkhani; Malihe Akbari
Volume 23, Issue 10 , 2021
Abstract
Context: Subacute thyroiditis has been classified as an autoinflammatory condition and is mainly caused by a viral infection. According to the pathogenesis of SARS-CoV2 infection, which is mainly based on the uncontrolled inflammatory immune response, several studies have investigated the possible association ...
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Context: Subacute thyroiditis has been classified as an autoinflammatory condition and is mainly caused by a viral infection. According to the pathogenesis of SARS-CoV2 infection, which is mainly based on the uncontrolled inflammatory immune response, several studies have investigated the possible association between SARS-CoV2 and subacute thyroiditis. The present study aimed to review and organize the studies that have investigated the possible association between SARS-CoV2 and subacute thyroiditis.
Evidence Acquisition: Initially, we observed and provided evidence on the possible roles and mechanisms of SARS-CoV2 in inflammatory and autoimmune diseases, and then we discussed the findings on the association between subacute thyroiditis and SARS-CoV2 infection.
Results: Investigation of other autoimmune and inflammatory disorders, and previous studies on the role of viruses in the pathogenesis of subacute thyroiditis, as well as studies on the inflammatory mechanism of SARS-CoV2 infection support the hypothesis that SARS-CoV2 may initiate subacute thyroiditis.
Conclusions: The existing evidence suggests that subacute thyroiditis should be considered a late symptom of COVID-19.
